He was tireless and devout, serving in every capacity he could. He spent hours in kneeling in the confessional, available for anyone who may need the sacrament of penance. He served as president of two different colleges. He worked doggedly to turn girls away from prostitution.
In time, he admitted that his legs felt as if they were slashed with thorns and on fire. Sounds like diabetic neuropathy to someone who knows more about that than I. More than Francis knew about it, too. All he knew was that he couldn't walk anymore, so when Mount Vesuvius was threatening to flood Naples with lava, Francis asked some friends to carry him to the base of the mountain. There he prayed, and there the lava ceased to advance.
Eventually, the anti-clerical attitude in Italy led to the expulsion of the Barnabites. In 1815, he had a vision of a deceased penitent who had promised to return to him before he died. This sign indicated that his own demise was at hand. Sure enough, he was gone within three days.